ISG Summer Meeting 2024

Themed Oral Presentations - Hepatology and Other GI
First Prize

Dr Aoife Moriarty
Mater Misericordiae University Hospital, Dublin

AUDIO Trial: Alcohol Use Disorder; Identification And Outcomes

TBA (24S159)

AUDIO Trial : Alcohol Use Disorder; Identification And Outcomes.

Author(s)

Dr Aoife Moriarty, Dr Paul Armstrong, Dr Jennifer Russell, Prof Stephen Stewart

Department(s)/Institutions

The Liver Centre, Mater Misericordiae University Hospital (MMUH), Dublin

Introduction

Alcohol remains a problem for Irish healthcare, at a cost of €1.5 billion/year. The complex interaction between physical harms and social problems makes this a difficult population to study.

Aims/Background

We aimed to describe patients admitted with an alcohol attributable illness (AAI) and assessed their quality of life, cognitive and frailty scores. Primary outcome was 6 month mortality, with secondary outcomes of OPD attendance, alcohol abstinence and improvements in scores at follow-up.

Method

This 1 year prospective study recruited 60 patients admitted under MMUH gastroenterology services. Demographics, social and alcohol consumption data, liver frailty index (LFI), quality of life (chronic liver disease questionnaire (CLDQ)) and Montreal cognitive assessment (MOCA) were collected. Follow-up occurred at 1,3,6months.

Results

78.3% were male, aged 58.82 years (+/-11.86 SD). 80% had a previous AAI admission, 31.7% within 3months. Mean historical alcohol consumption was 29.67 years (+/-14.5 SD) and median consumption 112 units of alcohol/week (100 IQR). 43.3% had decompensated cirrhosis. 6 month mortality was 11%. 55% attended at least 1 follow-up. Of those who followed-up, 1month alcohol abstinence was 76%. Baseline mean LFI was “frail” 4.5 (+/-1.03), mean CLDQ 3.74 (+/-1.07), median MOCA 22 (5.07 IQR). There was a statistically significant improvement in baseline CLDQ (Md3.38) to 1month (Md5.38), 3months (Md5.33) 6months (Md5.45) p=0.03, but no improvement in frailty or MOCA.

Conclusions

This young, frail cohort of patients with multiple hospitalisations have a high 6month mortality, low follow-up rates and considerable burden of symptoms by CLDQ scores. More needs to be done to improve outcomes in this cohort.

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