TBA (19W185)

Real World Experience with Tofacitinib for Moderate to Severe Ulcerative Colitis (UC)

Author(s)

R SAEIDI, A YADAV, C ROWAN, G CULLEN, J SHERIDAN, E SLATTERY, L EGAN, A O’TOOLE, C O’MORAIN, GA DOHERTY

Department(s)/Institutions

Centre for Colorectal Disease, St. Vincent’s University Hospital/UCD Medical School, UCHG and NUI Galway, Beaumont Hospital/RCSI, Trinity College Dublin/Beacon Hospital On behalf of the INITIative network

Introduction

Tofacitinib, an oral pan-JAK inhibitor with short half-life, was recently approved for induction and maintenance of remission in UC. Tofacitinib has been linked to several adverse effects including higher infection risk, VZV re-activation, hyperlipidaemia and PE.

Aims/Background

The aim of our study was to assess the safety and efficacy of tofacitinib in real world Irish practice.

Method

We performed a retrospective multi-centre study through the INITIative IBD network. Anonymised demographic data was collected. Non-response was defined as permanent discontinuation due to lack of efficacy, need for colectomy or adverse effects.

Results

Total of 18 patients were included with median therapy duration of 25 weeks, seventeen of which were on anti-TNF therapy prior to tofacitinib. Twelve (67%) were male. 12/18 patients (67%) responded to therapy, of which one discontinued therapy due to pregnancy. Median treatment duration was 31 weeks in responder group 6/18 (33%) patients were non-responders to therapy after a median of 17 weeks, 4 of whom underwent colectomy and 2 were referred for a surgical approach. 9/18 patients (50%) had concomitant maintenance medication(s); 2 of whom were on vedolizumab, 1 on methotrexate and the remainder on either oral 5-ASA or topical steroid/5-ASA, alone or in combination. There were 5 episodes of infection in 3 patients which required total of 38 days of therapy interruption. No other documented adverse effects of tofacitinib were recorded.

Conclusions

In our study majority of UC patients in real world Irish practice responded to tofacitinib. Further long term safety and efficacy registry of this medication would be beneficial.